Dr Ekwaro Obuku, Dr Alison Kinengyere, Dr Eve Namisango and Mr Robert Apunyo at the face-to-face strategic plan conception phase. Since its founding in 2013, the Africa Centre for Systematic Reviews and Knowledge Translation (Africa Centre MakCHS) has made tremendous achievements at Makerere University, Uganda and sub-Saharan Africa. Briefly, Africa Centre MakCHS has trained over 500 evidence generators or users, including students across over 10 countries in sub-Saharan Africa and produced over 50 evidence syntheses. Through this new strategic plan Centre is repositioning itself to meet the dynamic and evolving local and global (‘Glocal’) evidence ecosystem.